Promethazine is metabolized from the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing inside the urine.

The following laboratory tests could be affected in individuals who will be obtaining therapy with promethazine hydrochloride.

Antihistamines and codeine are each contraindicated for use within the therapy of reduce respiratory tract signs, which includes asthma.

Prevention and Charge of nausea and vomiting affiliated with particular forms of anesthesia and surgery.

There is no general agreement about precise pharmacological remedy regimens for uncomplicated NMS.

Head Injuries And Enhanced Intracranial Tension: The respiratory-depressant consequences of narcotic analgesics and their ability to elevate cerebrospinal fluid strain might be markedly exaggerated from the existence of head damage, intracranial lesions or even a preexisting boost in intracranial stress.

Promethazine HCl could be utilised on your own or as an adjunct to narcotic analgesics during labor (see DOSAGE AND ADMINISTRATION). Confined data counsel that usage of Promethazine through labor and shipping doesn't have an considerable effect on the period of labor or shipping and would not improve the hazard of have to have for intervention in the newborn.

Promethazine HCl and Codeine Phosphate Oral Resolution is indicated for your short-term aid of coughs and upper respiratory indications related to allergy or even the prevalent chilly in clients eighteen yrs of age and more mature.

Caution need to be exercised when administering Promethazine HCl Oral Answer to pediatric clients two many years of age and older as a result of possible for deadly respiratory melancholy. Respiratory melancholy and apnea, in some cases linked to Loss of life, are strongly affiliated with Promethazine products and therefore are indirectly connected with individualized excess weight-centered dosing, which could in any other case allow Secure administration.

Promethazine HCl Oral Option should be used for the duration of pregnancy provided that the potential advantage justifies the likely hazard into the fetus.

Make certain that individuals have an oral dosing dispenser that measures the appropriate quantity in milliliters. Counsel sufferers on how to benefit from an oral dosing dispenser and properly measure the oral suspension as prescribed.

Promethazine HCl Oral Option is contraindicated in comatose states, and in people today acknowledged to be hypersensitive or to acquire had an idiosyncratic reaction to Promethazine or to other phenothiazines.

Ambulatory patients must be told to stop participating in these actions right until it is known that they don't turn out to be drowsy or dizzy from promethazine and codeine therapy. Pediatric patients needs to be supervised in order to avoid prospective hurt in bicycle Using or in other dangerous activities.

Promethazine HCl could possibly be utilised on your own more info or being an adjunct to narcotic analgesics for the duration of labor (see DOSAGE AND ADMINISTRATION). Limited knowledge suggest that utilization of Promethazine throughout labor and shipping and delivery does not have an considerable impact on the duration of labor or shipping and delivery and does not boost the chance of require for intervention while in the newborn.